ホーム > 研究業績

2018

 

Yanagi, T., Watanabe, M., Hata, H., Kitamura, S., Imafuku, K., Yanagi, H., Homma, A., Wang, L., Takahashi, H., Shimizu, H. and Hatakeyama S.: Loss of TRIM29 alters keratin distribution to promote cell invasion in squamous cell carcinlma. Cancer Res., in press.

 

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama S., Matsumoto, M., Nakayama, K.I., Otsuka, Y., Sabe, H., Tsutsui, H. and Anzai, T.: Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure. Circulation, 138, 2064-2066, 2018.

 

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Watanabe, M. and Hatakeyama S.: Anti-Sez6l2 antibody, detected in a patient with immune-mediated cerebeller ataxia, inhibits complex formation of GluR1 and Sez6l2. J. Neurol., 265, 962-965, 2018.

 

Sang, Y., Li, Y., Song, L., Alvarez, A.A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., Hu, B., Cheng, S and Feng, H.: TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3. Cancer Res.,78, 1792-1804, 2018.

 

Yabe, I., Yaguchi, H., Kato, Y., Miki, Y., Takahashi, H.,Tanikiwa, S., Shirai, S., Takahashi, I., Kimura, M., Hama, Y., Matsushima, M., Fujioka, S., Kano, T., Watanabe, M., Nakagawa, S., Kunieda, Y., Ikeda, Y., Hasegawa, M., Nishihira, H., Ohtsuka, T., Tanaka, S., Tsuboi, Y., Hatakeyama, S., Wakabayashi, K. and Sasaki, H.: Mutations in basoon in individuals with familial and sporadic progressive supranuclear palsy. Sci. Rep., 8, 819, 2018.


2017

 

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K.I., Watanabe, M. and Hatakeyama, S.: Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem. Biophys. Res. Commun., 494, 234-241, 2017.

 

Watanabe, M. and Hatakeyama, S.: Fine-tuning of thymocyte development by ubiquitination-mediated stability control of the ESCRT protein CHMP5. Cell. Mol. Immunol. (Research Highlight), 14, 957-959, 2017.

 

Hatakeyama, S.: TRIM family proteins: roles in autophagy, immunity, and carcinogenesis. Trends Biochem. Sci., 42, 296-310, 2017.

 

Ibata, M., Iwasaki, J., Fujioka, Y., Nakagawa, K., Darmanin, S., Onozawa, M., Hashimoto, D., Ohba, Y., Hatakeyama, S., Teshima, T. and Kondo, T.: A leukemogenic kinase, FIP1L1-PDGFRA, and a SUMO E3, PIAS1, form a positive-crosstalk via their enzymatic activities. Cancer Sci., 108, 200-207, 2017.

 

Watanabe, M. and Hatakeyama, S.: TRIM proteins and diseases. J. Biochem., 161, 135-144, 2017.

 

Fujimoto, K., Kinoshita, M., Tanaka, H., Okuzaki, D., Shimada, Y., Kayama, H., Okumura, R., Furuta, Y., Narazaki, M., Tamura, A., Hatakeyama, S., Ikawa, M., Tsuchiya, K., Watanabe, M., Kumanogoh, A., Tsukita, S. and Takeda, K.: Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol., 10, 446-459, 2017.


2016

 

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K.I., Tsutsui, H. and Hatakeyama, S.: The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J. Mol. Cell. Cardiol., 100, 43-53, 2016.

 

Anwar, D., Takahashi, H., Watanabe, M., Suzuki, M., Fukuda, S. and Hatakeyama, S.: p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex. Biochim. Biophys. Acta-Gene Regul. Mech., 1859, 975-982, 2016.

 

Hatakeyama, S.: Early evidence for the role of TRIM29 in multiple cancer models. Expert Opin. Ther. Targets, 20, 767-770, 2016.

 

Otomo, K., Amengual, O., Fujieda, Y., Nakagawa, H., Kato, M., Oku, K., Horita, T., Yasuda, S., Matsumoto, M., Nakayama, K.I., Hatakeyama, S., Koike, T. and Atsumi, T.: Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-b2 glycoprotein I antibodies. Lupus, 25, 1288-1298, 2016.

 

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, Y., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K.I. and Atsumi, T.: Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes. Rheumatology, 55, 1117-1126, 2016.

 

Suzuki, M., Watanabe, M., Nakamaru, Y., Takagi, D., Takahashi, H., Fukuda, S. and Hatakeyama, S.: TRIM39 negatively regulates the NFkB-mediated signaling pathway through stabilization of cactin. Cell. Mol. Life Sci., 73, 1085-1101, 2016.

 

Kanno, Y., Mitsui, T., Kitta, T., Moriya, K., Tsukiyama, T., Hatakeyama, S. and Nonomura, K.: The inflammatory cytokine IL-1b is involved in bladder remodeling after bladder outlet obstruction in mice. Neurouro. Urodyn., 35, 377-381, 2016.


2015

 

Masuda, Y., Takahashi, H., Sato, S., Tomonori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W. and Hatakeyama, S.: TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nature Commun., 6, 7299, 2015.

 

Masuda, Y., Takahashi, H. and Hatakeyama, S.: TRIM29 regulates the p63-mediated pathway in cervical cancer cells. Biochim. Biophys. Acta-Mol. Cell Res., 1853, 2296-2305, 2015.

 

Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K. and Hatakeyama, S.: The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipocyte activator PPAR gamma. eLIFE, 4, e05615, 2015

 

Tsukiyama, T., Fukui, A., Terai, S., Fujioka, Y., Shinada, K., Takahashi, H., Yamaguchi, T.P., Ohba, Y.,  and Hatakeyama, S.: Molecular role of RNF43 in canonical and noncanonical Wnt signaling, Mol. Cell. Biol., 35, 2007-2023, 2015.

 

Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S.: MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex, Nature Commun., 6, 5941, 2015.

 

Sato,T., Takahashi, H., Hatakeyama, S., Iguchi, A. and Ariga, T.: The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway. Oncogene, 34, 1280-1291, 2015.

 

Nakamaru, Y., Takagi, D., Homma, A., Hatakeyama, S., Fukuda, S: Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase. Otolaryngol. Head Neck Surg., 152, 48-52, 2015.

 

Kameda, Y., Takahata, M., Mikuni, S., Shimizu, T., Hamano, H., Angata, T., Hatakeyama, S., Kinjo, M. and Iwasaki, N.: Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis. Bone, 71, 217-226, 2015.


2014

Yabe, I., Tanino, M., Yaguchi, H., Takiyama, A., Cai, H., Kanno, H., Takahashi, I., Hayashi, Y., Watanabe, M., Takahashi, H., Hatakeyama, S., Tanaka, S. and Sasaki, H.: Pathology of frontotemporal dementia with limb girdle muscular dystrophy caused by DNAJB6 mutation. Clin. Neurol. Neurosur., 127, 10-12, 2014.

 

Ai, L., Kim, W.J., Alpay, M., Tang, M., Pardo, C.E., Hatakeyama, S., May, W.S., Kladde, M.P., Heldermon, C.D., Siegel, E.M. and Brown, K.D.: TRIM29 suppresses TWIST1 and invasive breast cancer behavior. Cancer Res., 74, 4875-4887, 2014

 

Kanno, Y., Watanabe, M., Kimura, T., Nonomura, K., Tanaka, S. and Hatakeyama, S.: TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer. Acta Histochem., 116, 708-712, 2014.

 

Yaguchi, H., Yabe, I., Takahashi, H., Okumura, F., Takeuchi, A., Horiuchi, K., Kano, T., Kanda, A., Saito, W., Matsumoto, M., Nakayama, K.I., Hatakeyama, S. and Sasaki, H.: Identification of anti-Sez612 antibody in a patient with cerebellar ataxia and retinopathy. J. Neurol., 261, 244-246, 2014.


2013

Kameda., Y., Takahata, M., Komatsu, M., Mikuni, S., Hatakeyama, S., Shimizu, T., Angata, T., Kinjyo, M., Minami, A. and Iwasaki, N.: Siglec-15 regulates osteoclast cytoskeletal organization in association with signaling adaptor DAP12. J. Bone Mineral Res., 28, 2463-2475, 2013.

 

Ichimura, T., Taoka, M., Shoji, I., Kato, H., Sato, T., Hatakeyama, S., Isobe, T. and Hachiya, N.: 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitination and cytoplasmic body formation. J. Cell Sci., 126, 2014-2026, 2013.

 

Okumura, F., Okumura, A.J., Uematsu, K., Hatakeyama, S., Zhang, D.E. and Kamura, T.: Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates protein translation. J. Biol. Chem., 288, 2839-2847, 2013.


2012

Hatakeyama, S.: Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells. JAK-STAT, 1, 168-175, 2012.

 

Shibata, M., Sato, T., Nukiwa, R., Ariga, T. and Hatakeyama, S.: TRIM45 negatively regulates NF-kB-mediated transcription and suppresses cell prolifration. Biochem. Biophys. Res. Commun. 423, 104-109, 2012.

 

Kondo, T., Watanabe, M. and Hatakeyama, S.: TRIM59 interacts with ECSIT and negatively regulates NF-kB and IRF-3/7-mediated signal pathway. Biochem. Biophys. Res. Commun., 422, 501-507, 2012.

 

Tsukiyama, T., Matsuda-Tsukiyama, M., Bohgaki, M., Terai, S., Tanaka, S. and Hatakeyama, S.: Ymer acts as a multufunctional regulator in NF-kB and Fas signaling pathways. Mol. Med., 18, 587-597, 2012.

 

Sato, T., Okumura, F., Ariga, T. and Hatakeyama, S.: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonal stem cells. J. Cell Sci., 125, 1544-1555, 2012.

 

Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S.: TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis. J. Biol. Chem., 287, 12050-12059, 2012.

 

Tsukiyama, T. and Yamaguchi, T.P: Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype. Neurosci. Lett., 512, 48-52, 2012.

 

Sato, T., Okumura, F., Iguchi, A., Ariga, T. and Hatakeyama, S.: TRIM32 promotes retinoic acid receptor alpha-mediated differentiation in human promyelogenous leukemic cell line HL60. Biochem. Biophys. Res. Commun., 417, 594-600, 2012.


2011

Hatakeyama, S.: TRIM proteins and cancer. Nature Rev. Cancer, 11, 792-804, 2011.

 

Sato, T., Okumura, F., Kano, S., Kondo, T., Ariga, T. and Hatakeyama, S.: TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription. J. Cell Sci., 124, 3492-3502, 2011.

 

Okumura, F., Okumura, A.J., Matsumoto, M., Nakayama, K.I. and Hatakeyama, S.: TRIM8 regulates Nanog via Hsp90 beta-mediated nuclear translocation of STAT3 in embryonic stem cells. BBA-Mol. Cell Res., 1813, 1784-1792, 2011.

 

Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S. and Hatakeyama, S.: TRM40 promotes neddylation of IKK gamma and is downregulated in gastrointestinal cancers. Carcinogenesis, 32, 995-1004, 2011.

 

Sho, T., Tsukiyama, T., Sato, T., Kondo, T., Cheng, J., Saku, T., Asaka, M. and Hatakeyama, S.: TRIM29 negatively regulates p53 via inhibition of Tip60. BBA-Mol. Cell Res., 1813, 1245-1253, 2011.

 

Wu, H., Pomeroy, S.L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K.I., Hatakeyama, S., Tron, V.A., Saltibus, L.F., Spyracopoulos, L. and Leng, R.P.: UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nature Med., 17, 347-355, 2011.

 

Okumura, F., Yoshida, K., Liang, F. and Hatakeyama, S.: MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin binding motif. Mol. Cell. Biochem., 352, 163-172, 2011.

 

Sugiyama, N., Tsukiyama, T., Yamaguchi, T.P. and Yokoyama, T.: The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice. Kidney Int., 79, 957-965, 2011.

 

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K.I., Okumura, F., *Hatakeyama, S. and Koike, T.: Plasma gelsolin facilitates interaction between beta 2 glycoprotein I and alpha 5 beta 1 integrin. J. Cell. Mol. Med., 15, 141-151, 2011.
*corresponding autor

 

Shinada, K., Tsukiyama, T., Sho, T., Okumura, F., Asaka, M., Hatakeyama, S.: RNF43 interacts with NEDL1 and regulates p53-mediated transcription. Biochem. Biophys. Res. Commun., 404, 143-147, 2011.


2010

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K.I., Hatakeyama, S.: TRIM8 modulates STAT3 activity through negative regulation of PIAS3. J. Cell Sci., 123, 2238-2245, 2010.

 

Okumura, F., Kameda, H., Ojima, T., Hatakeyama, S.: Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines. Biochem. Biophys. Res. Commun., 395, 352-355, 2010.

 

Benirschke, R.C., Thompson, J.R., Nomine, Y., Wasielewski, E., Juranic, N., Macura, S., Hatakeyama, S., Nakayama, K.I., Botuyan, M.V., Mer, G.: Molecular basis for the association of human E4B U-box ubiquitin ligase with E2 conjugating enzymes UbcH5C and Ubc4. Structure, 18, 955-965, 2010.

 

Sasai, M., Tatematsu, M., Oshiumi, H., Funami, K., Matsumoto, M., Hatakeyama, S. and Seya, T.: Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Mol. Immunol., 47, 1283-1291, 2010.


2009

Suizu. F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A.J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S., Obata, T. and Noguchi, M: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell, 17, 800-810, 2009.

 

Kikuchi, M., Okumura, F., Tsukiyama, T., Watanabe, M., Miyajima, N., Tanaka, J., Imamura, M., Hatakeyama, S.: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. BBA-MCR. 1793, 1828-1836, 2009.

 

Yoshida. K., Watanabe, M., and Hatakeyama , S.: ZNRF1 interacts with tubulin and regulates cell morphogenesis. Biochem. Biophys. Res. Commun., 389, 506-511, 2009.

 

Watanabe, M., Tsukiyama, T. and Hatakeyama , S.: TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth. Biochem. Biophys. Res. Commun., 388, 422-427, 2009.

 

Maeda, H., Miyajima, N., Kano, S., Tsukiyama, T., Okumura, F., Fukuda, S. and Hatakeyama, S.: Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer. Mol. Cancer Res., 7, 1553-1562, 2009

 

Kimura, T., Sakai, M., Tabu, K., Wang, L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S. and Nakayama, K.I: Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Lab. Invest., 89, 645-656, 2009.

 

Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. and Nakayama, K.I.: Large-scale proteomic analysis of tyrosine phosphorylation induced by TCR or BCR activation reveals new signaling pathways. Proteomics, 9, 3549-3563, 2009.

 

Miyajima, N., Maruyama, S., Nonomura, K. and Hatakeyama , S.: TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle prograssion. Biochem. Biophys. Res. Commun., 381, 383-387, 2009.

 

Suzuki, K., Yamaguchi, Y., Villacorte, M., Hihara, K., Akiyama, M., Shimizu, H., Taketo, M.M., Nakagata, N., Tsukiyama, T., Yamaguchi, T.P., Birchmeier, W., Kato, S. and Yamada, G.: Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling. Development, 136, 367-372, 2009

 

Kameda, H., Watanabe, M., Bohgaki, M., Tsukiyama, T. and Hatakeyama, S.: Inhibition of NF-kB signaling via tyrosine phosphorylation of Ymer. Biochem. Biophys. Res. Commun., 378, 744-749, 2009

 

Oshiumi, H., Matsumoto, M., Hatakeyama, S. and Seya, T.: Riplet/RNF135, a RING-finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J. Biol. Chem., 284, 807-817, 2009


2008

Kano, S., Miyajima, N., Fukuda, S. and Hatakeyama, S.: TRIM32 facilitates cell growth and migration via degradation of Abl-interactor 2, Cancer Res., 68, 5572-5580, 2008.

 

Miyajima, N., Maruyama, S., Bohgaki, M., Kano, S., Shigemura, M., Shinohara, N., Nonomura, K. and Hatakeyama, S.: TRIM68 regulates ligand-dependent transcription of androgen receptorin prostate cancer cells, Cancer Res., 68, 3486-3494, 2008.

 

Bohgaki, M., Tsukiyama, T., Nakajima, A., Watanabe, M., Koike, T. and Hatakeyama,S.: Involvement of Ymer in suppression of NF-kB activation by regulated interaction with lysine-63-linked polyubiquitin chain, BBA-MCR., 1784, 826-837, 2008.

 

Takahata, M., Bohgaki, K., Tsukiyama, T., Kondo, T., Asaka, M.and Hatakeyama, S.: Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system, Mol. Immunol., 45, 2045-2054, 2008.

 

Maruyama, S., Miyajima, N., Bohgaki, M., Tsukiyama, T., Shigemura, M., Nonomura, K. and Hatakeyama, S.: Ubiquitylation of e-COP by PIRH2 and regulation of the secretion of PSA, Mol. Cell. Biochem., 307, 73-82, 2008.


2007

Sakane, A., Hatakeyama, S. and Sasaki, T.: Involvement of Rabring7 in EGF receptor degradation as an E3 ligase, Biochem. Biophys. Res. Commun., 357, 1058-1064, 2007.

 

Nakajima, A., Maruyama, S., Bohgaki, M., Miyajima, N., Tsukiyama, T., Sakuragi, N. and Hatakeyama, S.: Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP. Biochem. Biophys. Res. Commun., 357, 245-251, 2007.

 

Matsuda, M., Tsukiyama, T., Bohgaki, M., Nonomura, K. and Hatakeyama, S.: Establishment of a newly improved detection system for NF-kB activity. Immunol. Lett., 109, 175-181, 2007

 

Kishi, K., Mawatari, K., Sakai-Wakamatsu, K., Yuasa, T., Wang, M., Ogura-Sawa, M., Nakaya, Y., Hatakeyama, S. and Ebina, Y.: APS-mediated ubiquitination of the insulin receptor enhances its internalization, but does not induce its degradation. Endocri. J., 54, 77-88, 2007

 

Watanabe, M,. Tsukiyama, T., and Hatakeyama, S.: Protection of vincristine-induced neuropathy by Wlds expression and the independence of the activity of Nmnat1. Neurosci. Lett., 411,228-232, 2007


2006

Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, KI. Konno, H., and Kitagawa, M.: Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res., 66, 8477-8483, 2006.

 

Makino, Y., Tsuda, M., Ichihara, S., Watanabe, T., Sawa, H., Nagashima, K., Hatakeyama, S., and Tanaka, S.: Elmo1 inhibits ubiquitylation of Dock180. J. Cell Sci., 119, 923-932. 2006


2005

Kaneko-Oshikawa, C., Nakagawa, T., Yamada, M., Yoshikawa, H., Matsumoto, M., Yada, M., Hatakeyama, S., Nakayama, K., and Nakayama, K-i.: Mammalian E4 is required for cardiac development and maintenanceof the nervous system. Mol. Cell. Biol., 25, 10953-10964, 2005

 

Yogosawa, S., Hatakeyama, S., Nakayama, K-i., Miyoshi, H., Kohsaka, S., and Akasawa, C.: Ubiquitylation and degradation of polo-like kinase SNK by hVPS18, a RING-H2 type ubiquitin ligase. J. Biol. Chem., 280, 41619-41627, 2005

 

Hatakeyama, S., Watanabe, M., Fujii, Y. and Nakayama, K-i.: Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation. Cancer Res., 65, 7874-7879, 2005

 

Hatakeyama, S., Matsumoto, M. and Nakayama, K-i.: Mapping of ubiquitination sites on target proteins. Methods Enzymol., 399, 277-286, 2005

 

Pushkarsky, T., Yurchenko, V., Vanpouille, C., Brichacek, B., Vaisman, I. Hatakeyama, S., Nakayama, K.I., Sherry, B. and Bukrinsky M.I.: Cell surf CD147/emmprin is regulated by cyclophilin 60. J. Bio. Chem., 280, 27866-17871, 2005

 

Matsumoto, M., Hatakeyama, S., Oyamada, K., Oda, Y., Nishimura, T. and Nakayama. K-i.: Large-scale analysis of the human ubiquitin-related proteome. Proteomics, 5, 4145-4151, 2005

 

Takahashi. H., Hatakeyama, S., Saitoh H., Nakayama, K-i.: Title: Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein (PML). J. Biol. Chem. 280, 5611-5621, 2005


2004

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T., and Nakayama, K-i.: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J. Biol. Chem. 279, 53533-53543, 2004.

 

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., and Nakayama, K-i.: Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase. Nature Cell Biol. 6, 1229-1235, 2004.

 

Hatakeyama, S., Matsumoto, M., Kamura, T., Murayama, M., Du-Hua Chui, D-H., Planel, E., Takahashi, R., Nakayama, K-i., and Takashima, A.: U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J. Neurochem. 91, 299-307, 2004

 

Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, K-i., Yamamoto, H., Kikuchi, A., and Morohashi, K.: SUMO-1 modification of the synergy control motif of Ad4BP/SF-1 regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocronol., 18, 2451-2462, 2004.

 

Akiyoshi, H., Hatakeyama, S., Pitkanen J., Mouri, Y., Dougcas, V., Kudoh, J., Tsurugaya, K., Uchida, D., Matsushima, A., Oshikawa, K., Nakayama, K-i., Shimizu N., Peterson, P., and Matsumoto, M.: Subcellular expression of autoimmune regulator (AIRE) is organized in a spatiotemporal manner. J. Biol. Chem., 279, 33984-33991, 2004

 

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., and Nakayama, K-i.: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J., 23, 2116-2125, 2004

 

Nakayama K., Nagahama,H., Minamishima, Y.A., Miyake, S., Ishida, N., Hatakeyama, S., Iemura, S., Natsume, T., and Nakayama, K-i.: Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis. Dev. Cell, 6, 661-672, 2004.

 

Hatakeyama, S., Matsumoto, M., Yada, M., and Keiichi I. Nakayama, K-i.: Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Genes Cells, 9, 533-548, 2004

 

Urushitani, M., Kurisu, J., Tateno, M., Hatakeyama, S., Nakayama, K-i., Kato, S., and Takahashi, R.: CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J. Neurochem., 90, 231-244, 2004.

 

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N. Hatakeyama, S., Bessho, B., Kageyama, R., Suda, T., and Nakayama, K-i.: Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J. Biol. Chem., 279, 9417-9423, 2004.

 

Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M., and K-i. Nakayama.: Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J., 23, 659-669, 2004.

 

Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J, Shimizu, N., Doucas, V., Nakayama, KI., Kuroda, N., Matsumoto, M.: AIRE, a Protein Responsible for Autoimmunity, Functions as an E3 Ubiquitin Ligase. J. Exp. Med., 199, 167-172, 2004.

 

Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama KI. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol., 24, 8386-8394, 2004.

北海道大学 大学院医学研究院生理系部門
生化学分野 医化学教室
〒060-8638 札幌市北区北15条西7丁目
医学部 北研究棟 1階N1-111
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